ZAP-70: an essential kinase in T-cell signaling.
نویسندگان
چکیده
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.
منابع مشابه
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عنوان ژورنال:
- Cold Spring Harbor perspectives in biology
دوره 2 5 شماره
صفحات -
تاریخ انتشار 2010